On February 28, 2019, de O. Assis, Shalom P.; da Silva, Moara T.; da Silva, Filipe Torres; Sant’Anna, Mirella P.; de Albuquerque Tenorio, Carolina M. B.; dos Santos, Caroline F. Brito; da Fonseca, Caique S. M.; Seabra, Gustavo; Lima, Vera L. M.; de Oliveira, Ronaldo N. published an article.Category: bromides-buliding-blocks The title of the article was Design and synthesis of triazole-phthalimide hybrids with anti-inflammatory activity. And the article contained the following:
Phthalimido-alkyl-1H-1,2,3-triazole derivatives were efficiently synthesized using 1,3-dipolar cycloaddition reaction. Anti-inflammatory activity and toxicity studies were performed. The results demonstrated that all the tested compounds reduced carrageenan-induced paw edema and indicated no lethality for toxicity against Artemia salina and acute toxicity in vivo (LD50 up to 1 g kg-1). Furthermore, the structure of phthalimide linked to Ph group proved to be more active than the compounds containing benzothiazole moiety. Structural modifications such as removal of the phthalimide group and subsequent acetylation, to exemplify a non-cyclic amide, demonstrate that the phthalimide and triazole moieties were important for design of potent candidates with anti-inflammatory drug proprieties. Docking into the cyclooxygenase-2 (COX-2) confirmed the importance of the phthalimide and triazole groups in the anti-inflammatory activity. The histopathol. studies showed that the compounds did not cause serious pathol. lesions liver or kidneys. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks
The Article related to benzothiazolyl sulfanyl methyl phthalimidoylalkyl triazole regioselective preparation, phenyl phthalimido alkyl triazole regioselective preparation, antiinflammatory activity sar acute toxicity lipophilicity mol docking, anti-inflammatory activity, phthalimide, toxicity, triazole and other aspects.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary