On February 10, 2022, Chen, Chen published a patent.Related Products of 111010-07-2 The title of the patent was Preparation of cyclic iminopyridimdine compounds and their bicyclic derivatives as kinase inhibitors and uses thereof. And the patent contained the following:
Provided are the title compounds I [G1 = N or CRa; G2 = N or CRb; n = 1 or 2; m = 0-3; Ra and Rb = (independently) H, halo, CN, etc.; each R1 = (independently) halo, (un)substituted alkyl, alkoxy; or two R1 groups with the carbon atom they connect to form (un)substituted 4-7 membered carbocyclic or heterocyclic ring; R2 = H, (un)substituted alkyl, alkoxy, etc.; R3 = H, halo, (un)substituted alkyl, alkoxy; R4 = H, (un)substituted alkyl, heterocyclyl, etc.; and R5 = H, alkyl, or heterocyclyl; or NR4R5 = (un)substituted heterocyclyl or heteroaryl; with the provisos] or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to kinases such as MAPK, PDGFR, Src, PAKs, c-Kit, EphA2, EphB4, FGFR, Axl, and c-Met. E.g., a multi-step synthesis of II, starting from 4-amino-2-(methylthio)pyrimidine-5-carboxaldehyde and Me 2-(2,4-dichlorophenyl)acetate, was described. The effect of the exemplified compounds I on the activity of various kinases were assessed (data given for representative compounds I). The experimental process involved the reaction of 5-Bromo-4-chloro-2-fluoroaniline(cas: 111010-07-2).Related Products of 111010-07-2
The Article related to cyclic iminopyrimidine bicyclic derivative preparation kinase inhibitor antitumor, mapk pdgfr src pak kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation, ckit epha2 ephb4 kinase inhibitor imidazopyridopyrimidinamine pyridodipyrimidinamine preparation antitumor and other aspects.Related Products of 111010-07-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary