One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Application In Synthesis of 70-23-5
Haroon, Muhammad;Akhtar, Tashfeen;Yousuf, Muhammad;Tahir, Muhammad Nawaz;Rasheed, Lubna;Zahra, Syeda Saniya;Haq, Ihsan ul;Ashfaq, Muhammad research published 《 Synthesis, crystal structure, Hirshfeld surface investigation and comparative DFT studies of ethyl 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate》, the research content is summarized as follows. The Et 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate, a thiazole ester, was synthesized by refluxing 1-(2-nitrobenzylidene)thiosemicarbazide and Et bromopyruvate. The compound is characterized by spectrometric, spectroscopic and single crystal (SC-XRD) techniques. Non-covalent interactions that are responsible for crystal packing are explored by Hirshfeld surface anal. All theor. calculations were performed by DFT quantum chem. methods using 6-311G(d,p) and cc-pVTZ basis sets and compared. Theor. harmonic frequencies of Et 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate were optimized. Confirmation of hydrogen bonding sites was analyzed by mol. electrostatic potential (MEP) and Mulliken population anal. The vibrational frequencies of characteristic functional groups and chem. shifts were found in good agreement with exptl. assignments. Frontier MO (FMO) revealed relatively small HOMO-LUMO (HOMO-LUMO) gape, which speaks off the nearly planar geometry and extended conjugation, as compared to the substituents with no conjugation possible. It has also been observed that -NO2 substituent plays a vital role for this relatively small HOMO-LUMO gape and overall electronic properties when compared with similar thiazole carboxylates. Et 2-[2-(2-nitrobenzylidene)hydrazinyl]thiazole-4-carboxylate was also evaluated for its anti-oxidant and anti-microbial activities.
70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.
Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.
Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Application In Synthesis of 70-23-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary