Hao, Zesheng team published research in Molecular Diversity in 2022 | 70-23-5

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Reference of 70-23-5

Hao, Zesheng;Yu, Bin;Gao, Wei;Chen, Haoyin;Yang, Dongyan;Lv, You;Zhang, Yue;Chen, Lei;Fan, Zhijin research published 《 Design, synthesis and fungicidal activity of pyrazole-thiazole carboxamide derivatives》, the research content is summarized as follows. Twenty-one novel pyrazole-thiazole carboxamide derivatives were rationally designed and synthesized I [R = 2-(p-tolyl)ethyl, 2-(2-chlorophenyl)ethyl, 2-[4-(trifluoromethoxy)phenyl]ethyl, etc.] and II. Bioassay results indicated that I [R = 2-(p-tolyl)ethyl, 2-(2-chlorophenyl)ethyl] (EC50 = 5.11μg/mL), (EC50 = 8.14μg/mL) resp. exhibited better in-vitro activities than fluxapyroxad (EC50 = 11.93μg/mL) and thifluzamide (EC50 = 22.12μg/mL) against Rhizoctonia cerealis. Particularly, compound I [R = 2-(2-chlorophenyl)ethyl] showed promising in-vivo protective activity against Rhizoctonia solani and Puccinia sorghi Schw. with 80% and 90% inhibition at 10μg/mL, resp. Pyrazole-thiazole I was a promising fungicide lead deserving for further derivation.

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary