Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C7H6Br2.
Hahn, Michael G.;Lampe, Thomas;El Sheikh, Sherif;Griebenow, Nils;Woltering, Elisabeth;Schlemmer, Karl-Heinz;Dietz, Lisa;Gerisch, Michael;Wunder, Frank;Becker-Pelster, Eva-Maria;Mondritzki, Thomas;Tinel, Hanna;Knorr, Andreas;Kern, Armin;Lang, Dieter;Hueser, Joerg;Schomber, Tibor;Benardeau, Agnes;Eitner, Frank;Truebel, Hubert;Mittendorf, Joachim;Kumar, Vijay;van den Akker, Focco;Schaefer, Martina;Geiss, Volker;Sandner, Peter;Stasch, Johannes-Peter research published ã?Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)ã? the research content is summarized as follows. Herein we describe the discovery, mode of action, and preclin. characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of cyclic guanosine monophoshphate, is a key regulator of body and tissue homeostasis. sGC activators with their unique mode of action are activating the oxidized and heme-free and therefore NO-unresponsive form of sGC, which is formed under oxidative stress. The first generation of sGC activators like cinaciguat or ataciguat exhibited limitations and were discontinued. We overcame limitations of first-generation sGC activators and identified a new chem. class via high-throughput screening. The investigation of the structure-activity relationship allowed to improve potency and multiple solubility, permeability, metabolism, and drug-drug interactions parameters. This program resulted in the discovery of the oral sGC activator runcaciguat (compound 45, BAY 1101042). Runcaciguat is currently investigated in clin. phase 2 studies for the treatment of patients with chronic kidney disease and nonproliferative diabetic retinopathy.
823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.
3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Formula: C7H6Br2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary