A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 3-Bromobenzoic acid.
Gurram, Swarupa Rani;Azam, Mohammed Afzal research published ã?Design, synthesis and biological evaluation of some novel N’-(1,3-benzothiazol-2-yl)-arylamide derivatives as antibacterial agentsã? the research content is summarized as follows. Hydroxybenzotriazole (HOBT) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCl)-mediated synthesis of new N’-(1,3-benzothiazol-2-yl)-arylamides, I [R = 2-thienyl, 2-fluorophenyl, 4-oxochroman-3-yl, etc.] was carried out in high yields under relatively milder reaction conditions using DMF as solvent. Synthesized compounds I were characterized by FTIR, 1H-NMR, 13C-NMR and HRMS spectral data. The MIC values of synthesized compounds I were determined by the broth microdilution method using Mueller Hinton medium. Tested compounds I showed variable activity against the tested Gram-pos. and Gram-neg. bacterial strains. Compounds I [R = 2,6-dichlorophenyl, 4-chloro-3-nitrophenyl; R = 3-bromophenyl, 2-iodophenyl; R = 2-thienyl, 2-quinolyl, 1H-indol-2-ylmethyl] exhibited promising activity against Staphylococcus aureus NCIM 5021 with MIC values in the range of 19.7-24.2μM. Among all tested compounds, I [R = 2-thienyl] possessing thiophene ring attached to the benzothiazole moiety via amide linkage exhibited maximum activity against S. aureus NCIM 5022 with MIC of 13.0μM. Compound I [R = 2-thienyl] showed maximum activity against S. aureus ATCC 43300 with MIC of 15.0μM and exhibited bactericidal activity against this strain in min. bactericidal concentration determination This compound also eliminated S. aureus ATCC 43300 strain after 24-h exposure indicating its bactericidal activity. ADMET calculation showed favorable pharmacokinetic profile of synthesized compounds I.
Recommanded Product: 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary