Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Related Products of 585-76-2.
Ganesan, Moorthiamma Sarathy;Raja, Kamatchi Kanmani;Murugesan, Sankaranarayanan;Karankumar, Banoth;Faheem, Faheem;Thirunavukkarasu, Sappanimuthu;Shetye, Gauri;Ma, Rui;Franzblau, Scott G.;Wan, Baojie;Rajagopal, Gurusamy research published ã?Quinoline-Proline, Triazole Hybrids: Design, Synthesis, Antituberculosis, Molecular Docking, and ADMET Studiesã? the research content is summarized as follows. A series of novel quinoline-proline hybrids I (R = Ph, 4-fluorophenyl, 4-benzoylphenyl, etc.) and quinoline-proline-1,2,3-triazole hybrids II (R1 = OH, ethyloxidanyl, phenylaminyl) were synthesized by click chem. based on mol. hybridization concept and characterized by NMR, mass spectrometry, and elemental anal. All the titled target compounds I and II were tested for antitubercular activity by MABA and LORA methods by in vitro. Interestingly, two compounds I [R = 4-nitrophenyl (III) and 4-fluorophenyl (IV)] exhibited significant activity against the tested Mycobacterium tuberculosis H37Rv strain. Further, the cytotoxicity (CC50) profile of the titled compounds against the Vero cell was performed and discussed. A mol. docking study of the hit compounds III and IV was also performed to find their putative binding interaction with the active site of the target proteins. Finally, in silico ADMET properties were also predicted for all the synthesized mols. to evaluate their drug-likeness behavior.
Related Products of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary