Recommanded Product: 14660-52-7In 2019 ,《Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Zhao, Yunjie; Cao, Yongkai; Chen, Huizhen; Zhuang, Fei; Wu, Chao; Yoon, Goo; Zhu, Weiwei; Su, Ying; Zheng, Suqing; Liu, Zhiguo; Cheon, Seung Hoon. The article conveys some information:
We describe herein the design, synthesis, and biol. evaluation of a series of novel protein tyrosine phosphatase 1B (PTP1B) inhibitor retrochalcones having an allyl chain at the C-5 position of their B ring. Biol. screening results showed that the majority of these compounds exhibited an inhibitory activity against PTP1B. Thus, preliminary structure-activity relationship (SAR) and quant. SAR analyses were conducted. Among the compounds, 23 was the most potent inhibitor, exhibiting the highest in vitro inhibitory activity against PTP1B with an IC50 of 0.57 μM. Moreover, it displayed a significant hepatoprotective property via activation of the IR pathway in type 2 diabetic db/db mice. In addition, the results of our docking study showed that 23, as a specific inhibitor of PTP1B, effectively transformed the WPD loop from “”close”” to “”open”” in the active site. These results may reveal suitable compounds for the development of PTP1B inhibitors. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary