Quality Control of Ethyl 4-bromobutyrateIn 2019 ,《A Scalable Total Synthesis of Halofuginone》 was published in Organic Process Research & Development. The article was written by Xu, Hua; Yin, Wenhao; Liang, Haoqiang; Nan, Yanbo; Qiu, Fayang; Jin, Yehua. The article contains the following contents:
A scalable total synthesis of halofuginone (I) has been accomplished. This synthetic route features a total of 12 steps of highly efficient reactions, without any chromatog. purification Halofuginone was obtained in 17% overall yield and over 98.5% HPLC purity. All the reaction conditions are mild and reliable. In addition, no hazardous materials are used or produced. All reagents are com. available and inexpensive. This route is safe, robust, scalable, cost-effective, and environmentally benign.Ethyl 4-bromobutyrate(cas: 2969-81-5Quality Control of Ethyl 4-bromobutyrate) was used in this study.
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 4-bromobutyrate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary