《Novel phenethylimidazolium based ionic liquids: Design, microwave synthesis, in-silico, modeling and biological evaluation studies》 was written by Titi, Abderrahim; Almutairi, Saud M.; Alrefaei, Abdulwahed F.; Manoharadas, Salim; Alqurashy, Bakheet A.; Sahu, Pramod K.; Hammouti, Belkheir; Touzani, Rachid; Messali, Mouslim; Ali, Imran. Synthetic Route of C7H13BrO2 And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:
An eco-friendly preparation method for the novel bioactive imidazolium ionic liquids halides (ILs) was developed under microwave-assisted conditions. Synthesized ILs were characterized by spectroscopic techniques. Selected ILs were investigated for their antimicrobial activity against highly resistant Gram-pos. and Gram-neg. bacterial strains. Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-iumchloride (4) showed high antimicrobial activity against the Staphylococcus aureus strain in the inhibition zone tests and displayed low MIC and MBC levels against almost all tested bacteria. Furthermore, the ILs were screened in vitro against human hepatocellular carcinoma (HepG-2), human breast adenocarcinoma (MCF-7), and human colon carcinoma (Caco-2) cell lines. The screening results showed excellent to moderate anticancer activity across the ILs. Among the synthesized ILs, Overall, 3-(2-chlorobenzyl)-1-phenethyl-1H-imidazol-3-ium chloride (4) and 1-phenethyl-3-(3-phenoxypropyl)-1H-imidazol-3-ium bromide (7) were found to exhibit the most promising ant proliferative effects and had the lowest IC50 values. The docking study suggested strong interaction of ILs with DNA with binding energy ranging from -4.9 to -4.1 kcal/mol. ILs 4 and 7 were most strongly bonded with -4.9 and -4.8 kcal/mol binding energy; confirming in vitro anticancer results. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary