In 2019,Pharmacia (Sofia, Bulgaria) included an article by Severina, Hanna I.; Skupa, Olha O.; Voloshchuk, Natalya I.; Suleiman, Marharyta M.; Georgiyants, Victoriya A.. Recommanded Product: Benzyl 2-bromoacetate. The article was titled 《Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio) pyrimidin-4(3H)-one derivatives and products of their cyclization》. The information in the text is summarized as follows:
The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one with phenacyl bromides RC6H4C(O)CH2Br (R = H, 4-Br, 3-OMe, 4-OMe, 4-F, 4-NO2), bromo-acetic acid benzyl ester under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3, a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-ones I and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-ones II was formed. The holding of the resulting mixture in the concentrated sulfuric acid leads to the formation of cyclization products III with high yields. Individual S-alkylated derivatives I, benzyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetate were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacol. screening of synthesized compounds I (R = H, 4-Br, 3-OMe, 4-OMe), III, benzyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetate for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “”structure-activity”” was established. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: Benzyl 2-bromoacetate)
Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Recommanded Product: Benzyl 2-bromoacetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary