In 2016,Schmidt, Andrea; Molano, Viviana; Hollering, Manuela; Poethig, Alexander; Casini, Angela; Kuehn, Fritz E. published 《Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin》.Chemistry – A European Journal published the findings.Name: 3,5-Dibromoaniline The information in the text is summarized as follows:
Self-assembled metallocages are very promising drug-delivery systems among supramol. complexes. Thus, exo-functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl-functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat-liver tissues using the precision cut-tissue slices technol., demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self-assembled Pd2L4 cages for biol. applications. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: 3,5-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary