Category: bromides-buliding-blocksIn 2020 ,《Synthesis and Characterization of a Series of Sulfamethazine Multicomponent Crystals with Various Benzoic Acids》 was published in Crystal Growth & Design. The article was written by Scheepers, Matthew C.; Lemmerer, Andreas. The article contains the following contents:
Nine multi-component crystals consisting of sulfamethazine (sz) with HOBz and its derivatives were synthesized and characterized. Eight of the 9 multi-component crystals are co-crystals, while 1 is a mol. salt. The co-formers used to form multi-component crystals with sz include: 2-chloro-4-nitrobenzoic acid (2c4n), 2-chloro-5-nitrobenzoic acid (2c5n), salicylic acid (2hba), 3-hydroxybenzoic acid (3hba), 4-hydroxybenzoic acid (4hba), 4-bromobenzoic acid (4Brba), HOBz (ba), cinnamic acid (ca) and toluic acid (ta). These multi-component crystals were characterized by single-crystal x-ray diffraction (SC-XRD), Powder X-ray diffraction (PXRD) and Differential Scanning Calorimetry (DSC). SC-XRD showed that 8 of the co-formers that interacted with sz formed the amidine-carboxyl synthon; with the only exception to this were sz+4hba which formed the imidine-carboxyl synthon formed instead. PXRD confirmed that the single crystals were representative of the bulk material. DSC showed most of the multi-component crystals to have only a melting phase transition, which differed from the m.ps. of the co-formers. The only exceptions were sz+4brba and sz+ca, where an addnl. endothermic peak was observed, which corresponds to an amorphous phase transition before melting. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary