Ramachandran, P. Veeraraghavan; Hamann, Henry J. published their research in Organic Letters in 2021. The article was titled 《Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids》.Name: 4-Bromobenzoic acid The article contains the following contents:
Ammonia-borane serves as an efficient substoichiometric (10%) precatalyst for the direct amidation of both carboxylic acids RC(O)OH (R = Me, Ph, cyclohexyl, pyridin-2-yl, etc.) with amines R1NHR2 [R1 = hexyl, cyclohexyl, Bn, etc.; R2 = H, Me, pentyl, Bn; R1R2 = -(CH2)5-] for the preparation of carboxamides RC(O)N(R1)R2. In situ generation of amine-boranes R1NH(R2)BH3 precedes the amidation and, unlike the amidation with stoichiometric amine-boranes, this process is facile with 1 equiv of the acid. This methodol. has high functional group tolerance and chromatog.-free purification but is not amenable for esterification. The latter feature has been exploited to prepare hydroxyl- and thiol-containing amides RC(O)N(R1)R2 (R = 2-phenylethyl, R1 = 2-hydroxyethyl, R2 = H; R = Ph, R1 = 2-sulfanylethyl, R2 = H). In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Name: 4-Bromobenzoic acid)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Name: 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary