In 2022,Panagiotakis, Stylianos; Mavroidi, Barbara; Athanasopoulos, Alexandros; Charalambidis, Georgios; Coutsolelos, Athanassios G.; Paravatou-Petsotas, Maria; Pelecanou, Maria; Mavridis, Irene M.; Yannakopoulou, Konstantina published an article in Carbohydrate Polymers. The title of the article was 《Unsymmetrical, monocarboxyalkyl meso-arylporphyrins in the photokilling of breast cancer cells using permethyl-β-cyclodextrin as sequestrant and cell uptake modulator》.Computed Properties of C7H13BrO2 The author mentioned the following in the article:
In the search for photosensitizers with chem. handles to facilitate their integration into complex drug delivery nanosystems, new, unsym. substituted, water insoluble meso-tetraphenylporphyrin and meso-tetra(m-hydroxyphenyl)porphyrin derivatives bearing one carboxyalkyl side chain were synthesized. Permethyl-β-cyclodextrin (pMβCD) was their ideal monomerizing host and highly efficient shuttle to transfer them into water. New assembly modes of the extremely stable (Kbinding > 1012 M-2) 2:1 complexes were identified. The complexes are photostable and do not disassemble in FBS-containing cell culture media for 24 h. Incubation of breast cancer MCF-7 cells with the complexes results in intense intracellular fluorescence, strongly enhanced in the endoplasmic reticulum (ER), high photokilling efficiency (∼90%) and low dark toxicity. pMβCD stands out as a very capable mol. isolator of mono-carboxyalkyl-arylporphyrins that increases uptake and modulates their localization in the cells. The most efficient porphyrins are envisaged as suitable photosensitizers that can be linked to biocompatible drug carriers for photo- and chemo-therapy applications. In the experimental materials used by the author, we found Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Computed Properties of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary