In 2022,Motornov, Vladimir A.; Tabolin, Andrey A.; Ioffe, Sema L. published an article in New Journal of Chemistry. The title of the article was 《Oxidative [3+2]-annulation of nitroalkenes and azolium ylides in the presence of Cu(II): efficient synthesis of [5,5]-annulated N-fused heterocycles》.Computed Properties of C9H9BrO2 The author mentioned the following in the article:
A facile synthesis of [5,5]-annulated N-fused heterocycles – pyrrolo[2,1-b]thiazoles and pyrrolo[1,2-b]indazoles via oxidative [3+2]-annulation between nitroalkenes and azolium ylides in the presence of copper(II) was developed. The reaction proceeds in mild conditions with the copper(II) trifluoroacetate/2,6-lutidine system. The method is applicable to a broad range of nitroalkenes and azolium salts, providing the target N-fused heterocycles in moderate to good yields. In the case of α-fluoronitroalkenes, unique fluorinated derivatives were accessed via this methodol. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)
Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Computed Properties of C9H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary