In 2018,Knerr, Laurent; Giordanetto, Fabrizio; Nordberg, Peter; Pettersen, Daniel; Selmi, Nidhal; Beisel, Hans-Georg; de la Motte, Hannah; Olsson, Thomas; Perkins, Tim D. J.; Hersloef, Margareta; Maansson, Aasa; Dahlstroem, Mikael; Starke, Ingemar; Broddefalk, Johan; Saarinen, Gabrielle; Klingegaard, Fredrik; Hurt-Camejo, Eva; Rosengren, Birgitta; Brengdahl, Johan; Jansen, Frank; Rohman, Mattias; Sandmark, Jenny; Hallberg, Kenth; Aakerud, Tomas; Roth, Robert G.; Ahlqvist, Marie published 《Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors》.ACS Medicinal Chemistry Letters published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:
In order to assess the potential of sPLA2-X as a therapeutic target for atherosclerosis, novel sPLA2 inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked on a lead generation effort that resulted in the identification of a novel series of indole-2-carboxamides as selective sPLA2-X inhibitors with excellent potential for further optimization. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Safety of Methyl 3-(bromomethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary