Safety of Ethyl 4-bromobutyrateIn 2019 ,《Tetraphenylporphyrin-based dual-functional medical agent for magnetic resonance and fluorescence imaging》 was published in Applied Organometallic Chemistry. The article was written by Jin, Manyu; Zhang, Yanqun; Gao, Ge; Xi, Qiaoyue; Tong, Jie; Zhao, Yongxia; Wu, Cunqi; Zhou, Hua; Yang, Qiuxia; Yang, Wei; Xu, Jingwei. The article contains the following contents:
A bimodal magnetic resonance imaging contrast agent, TPP-M-Gd, was developed by modifying tetraphenylporphyrin (TPP) with a small dendritic mol. as a ligand (M) to chelate gadolinium (Gd) ions. The ligand featured four carboxylate groups, which contributed to good water solubility and a strong combination with metal ions. The longitudinal relaxivity (R1) of the resulting agent is 12.45 mM-1s-1, which is much higher than that of DTPA-Gd (4.49 mM-1s-1). The magnetic resonance imaging experiments showed that the newly synthesized contrast agent could enhance T1-weighted magnetic resonance imaging quality both in vitro and in vivo. In addition, TPP-M-Gd exhibited good fluorescent property as shown in cell imaging experiments The cytotoxicity of TPP-M-Gd was even better than that of clin. approved DTPA-Gd, which makes it a promising dual-functional medical imaging agent to provide more detailed information about biol. and disease-related events. In the experiment, the researchers used Ethyl 4-bromobutyrate(cas: 2969-81-5Safety of Ethyl 4-bromobutyrate)
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Ethyl 4-bromobutyrate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary