Hwang, Nicky; Sun, Liren; Noe, Daisy; Lam, Patrick Y. S.; Zhou, Tianlun; Block, Timothy M.; Du, Yanming published an article in 2021. The article was titled 《Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation》, and you may find the article in ACS Medicinal Chemistry Letters.Reference of Ethyl 5-bromovalerate The information in the text is summarized as follows:
Chronic hepatitis B (CHB) is characterized by high levels of hepatitis B virus (HBV) surface antigen (HBsAg) in blood circulation. A major goal of CHB interventions is reducing or eliminating this antigenemia; however, there are currently no approved methods that can do this. A novel family of compounds with a dihydroquinolizinone (DHQ) scaffold has been shown to reduce circulating levels of HBsAg in animals, representing a first for a small mol. Reductions of HBsAg were a result of the compound’s effect on HBsAg mRNA levels. However, com. development by Roche of a DHQ lead compound, RG-7834, was stopped due to undisclosed toxicity issues. Herein we report our effort to convert the systemic RG7834 compound to a hepatoselective DHQ analog to limit its distribution to the bloodstream and thus to other body tissues. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Reference of Ethyl 5-bromovalerate)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Reference of Ethyl 5-bromovalerate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary