The author of 《Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists》 were Festa, Carmen; Finamore, Claudia; Marchiano, Silvia; Di Leva, Francesco Saverio; Carino, Adriana; Monti, Maria Chiara; del Gaudio, Federica; Ceccacci, Sara; Limongelli, Vittorio; Zampella, Angela; Fiorucci, Stefano; De Marino, Simona. And the article was published in ACS Medicinal Chemistry Letters in 2019. Related Products of 3395-91-3 The author mentioned the following in the article:
Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In total, 35 new derivatives were designed and synthesized, and notably, compounds I and II, containing a piperidine ring, displayed the best antagonistic activity against FXR with promising cellular potency (IC50 = 0.58 ± 0.27 and 0.127 ± 0.02 μM, resp.). The excellent pharmacokinetic properties make compound I the most promising lead identified in this study. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Related Products of 3395-91-3)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Related Products of 3395-91-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary