Recommanded Product: 76006-33-2In 2014 ,《Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei》 appeared in Journal of Medicinal Chemistry. The author of the article were Ferrins, Lori; Gazdik, Michelle; Rahmani, Raphael; Varghese, Swapna; Sykes, Melissa L.; Jones, Amy J.; Avery, Vicky M.; White, Karen L.; Ryan, Eileen; Charman, Susan A.; Kaiser, Marcel; Bergstrom, Christel A. S.; Baell, Jonathan B.. The article conveys some information:
A whole-organism screen of approx. 87000 compounds against Trypanosoma brucei identified a number of promising compounds for medicinal chem. optimization. One of these classes of compounds the authors termed the pyridyl benzamides. While the initial hit had an IC50 of 12 μM, it was small enough to be attractive for further optimization, and the authors utilized three parallel approaches to develop the structure-activity relationships. The authors determined that the physicochem. properties for this class are generally favorable with particular positions identified that appear to block metabolism when substituted and others that modulate solubility The most active compound is 79, which has an IC50 of 0.045 μM against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 times less active against the mammalian L6 cell line. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Recommanded Product: 76006-33-2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary