In 2019,Journal of Organic Chemistry included an article by Ding, Shao-Lei; Ji, Yang; Su, Yan; Li, Rui; Gu, Peiming. Synthetic Route of C7H13BrO2. The article was titled 《Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids》. The information in the text is summarized as follows:
The Schmidt reaction of ω-azido valeryl chlorides in the presence of an addnl. nucleophile was explored. The arenes, alcs., and amines were demonstrated as the intermol. trapping reagents for isocyanate ion and N-acyliminium ion from the Schmidt rearrangement, affording the corresponding products with moderate to excellent yields. Two 2-oxoindoles from the reaction were successfully converted into four natural alkaloids, namely, assoanine, anhydrolycorine, oxoassoanine, and anhydrolycorinone. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Synthetic Route of C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Synthetic Route of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary