The author of 《Nucleophilic aromatic substitution reactions of unactivated aryl halides with thiolate ions in hexamethylphosphoramide》 were Cogolli, Pietro; Maiolo, Filippo; Testaferri, Lorenzo; Tingoli, Marco; Tiecco, Marcello. And the article was published in Journal of Organic Chemistry in 1979. Application In Synthesis of 1-Bromo-3-(isopropylsulfonyl)benzene The author mentioned the following in the article:
A simple, high-yields method for the synthesis of aryl thioethers via nucleophilic displacement of unactivated aryl halides by the sodium salts of thiols in hexamethylphosphoramide (HMPA) is reported. The reactions proceed by the bimol. displacement mechanism SNAr. Competitive experiments showed that the four halobenzenes presented comparable reactivities toward isopropanethiol anions; the relative halogen mobility was I > F > Br > Cl. The effect of some substituents on the reactivity of chlorobenzene were also measured.1-Bromo-3-(isopropylsulfonyl)benzene(cas: 70399-01-8Application In Synthesis of 1-Bromo-3-(isopropylsulfonyl)benzene) was used in this study.
1-Bromo-3-(isopropylsulfonyl)benzene(cas: 70399-01-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 1-Bromo-3-(isopropylsulfonyl)benzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary