In 2022,Cheng, Yingjie; Qu, Zhonghua; Chen, Shiru; Ji, Xiaochen; Deng, Guo-Jun; Huang, Huawen published an article in Advanced Synthesis & Catalysis. The title of the article was 《Visible-Light-Induced Photoredox 1,1-Dichloromethylation of Alkenes with Chloroform》.Reference of 3,5-Dibromoaniline The author mentioned the following in the article:
A photoredox 1,1-dichloromethylation of alkenes RC(O)C(R1)=CHR2 (R = propylamino, anilino, 2,3-dihydroindol-1-yl, etc.) with the readily available bulk chem. chloroform was described, furnishing a variety of 1,1-dichloroalkane products RC(O)C(R1)C(R2)(CHCl2) selectively. Furthermore, this transformation could proceed smoothly on gram-scale, and the obtained products could transform into diverse γ-lactam derivatives such as 3-methyl-1-phenyl-1H-pyrrol-2(5H)-one, 5-methoxy/5-hydroxy-3-methyl-1-phenylpyrrolidin-2-one with simple treatment. Mechanistically, the single electron transfer (SET) with excited photocatalyst and subsequent deprotonation of triethylamine generates the key α-aminoradical intermediate, which enables selective Cl-atom transfer of chloroform. The specific selectivity, broad substrate scope, as well as the mild reaction conditions make this strategy especially attractive. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Reference of 3,5-Dibromoaniline)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of 3,5-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary