Zhang, Hai-Lin; Yu, Ya-Ting; Wang, Yi; Tang, Qi; Yang, Shi-Ping; Liu, Jin-Gang published an article in 2021. The article was titled 《Visible light-controlled carbon monoxide delivery combined with the inhibitory activity of histone deacetylases from a manganese complex for an enhanced antitumor therapy》, and you may find the article in Journal of Inorganic Biochemistry.Synthetic Route of C5BrMnO5 The information in the text is summarized as follows:
Multifunctional drugs with synergistic effects have been widely developed to enhance the treatment efficiency of various diseases, such as malignant tumors. Herein, a novel bifunctional manganese(I)-based prodrug [MnBr(CO)3(APIPB)] (APIPB = N-(2-aminophen-yl)-4-(1H-imidazo[4,5-f] [1, 10] phenanthrolin-2-yl)benzamide) with inhibitory histone deacetylase (HDAC) activity and light-controlled carbon monoxide (CO) delivery was successfully designed and synthesized. [MnBr(CO)3(APIPB)] readily released CO under visible light irradiation (λ > 400 nm) through which the amount of released CO could be controlled by manipulating light power d. and illumination time. In the absence of light irradiation, the cytotoxic effect of [MnBr(CO)3(APIPB)] on cancer cells was greater than that of the com. available HDAC inhibitor MS-275. Consequently, with a combination of CO delivery and HDAC inhibitory activity, [MnBr(CO)3(APIPB)] showed a remarkably enhanced antitumor effect on HeLa cells (IC50 = 3.2μM) under visible light irradiation Therefore, this approach shows potential for the development of medicinal metal complexes for combined antitumor therapies. In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Synthetic Route of C5BrMnO5)
Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Synthetic Route of C5BrMnO5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary