In 2019,Angewandte Chemie, International Edition included an article by Yi, Hong; Mao, Wenbin; Oestreich, Martin. Recommanded Product: 2969-81-5. The article was titled 《Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling》. The information in the text is summarized as follows:
An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5)
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 2969-81-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary