Weglarz, Izabela; Michalak, Karol; Mlynarski, Jacek published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks》.Quality Control of 1-Bromo-2-isopropylbenzene The article contains the following contents:
The first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex was reported. In situ generated zinc-ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2-aryl-substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodol. was demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Quality Control of 1-Bromo-2-isopropylbenzene)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Quality Control of 1-Bromo-2-isopropylbenzene Organobromine compounds have fallen under increased scrutiny for their environmental impact.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary