Wang, Xiaoju; Li, Ying; Zhou, Sirong; Feng, Liheng published their research in Shanxi Daxue Xuebao, Ziran Kexueban in 2021. The article was titled 《Effective antibacterial agent with double arm clamp configuration for treatment of wound infections》.Application In Synthesis of 1,4-Bis(bromomethyl)benzene The article contains the following contents:
Pathogenic bacteria are always one of threat to human health. Developing novel and effective bactericides to replace current antibiotics is significant and imperative. A pyridine quaternary ammonium salt with double arm clamp configuration as an antibacterial material was designed and synthesized. By taking advantage of the bridging role and electron donating action of 2,2′-bis(4-(bromomethyl)benzyloxy)-1,1′-dinaphthalene, two pyridine mols. can join together to obtain increased pos. charges and antibacterial acivity. The synthesized antibacterial material can effectively kill three common pathogenic bacteria including Escherichia coli (ampicillin-resistant), Pseudomonas aeruginosa, and Salmonella typhimurium at a low concentration The mechanism of membrane-disrupted is proved to be related to the interaction with lipopolysaccharide. Furthermore, it is successfully applied to the treatment of bacteria-infected wound of living mice without obvious biotoxicity. In the experiment, the researchers used 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Application In Synthesis of 1,4-Bis(bromomethyl)benzene)
1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 1,4-Bis(bromomethyl)benzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary