In 2022,Tajammal, Affifa; Siddiqa, Aysha; Irfan, Ahmad; Azam, Muhammad; Hafeez, Huma; Munawar, Munawar Ali; Basra, Muhammad Asim Raza published an article in Journal of Molecular Structure. The title of the article was 《Antioxidant, molecular docking and computational investigation of new flavonoids》.Application of 6630-33-7 The author mentioned the following in the article:
Flavonoids are a group of polyphenolic compounds diverse in structure, biol. and pharmacol. functions possessing antioxidant potential. New flavonoids I (R = 2-Br, 4-Br), II (R = 3-Br, 4-Br), 2,5-(OH)2C6H3C(O)CH=CHC6H4R (III) (R = 2-Br, 3-Br), were synthesized by acid catalyzed condensation of bromo-benzaldehydes RC6H4CHO and 2,5-dihydroxyacetophenone. In vitro antioxidant potential of synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation (ABTS+) radical scavenging, iron chelating, iron reducing and phosphomolybdenum activity. The results revealed that DPPH radical scavenging and ABTS+scavenging activity of compounds III were better than reference compounds i.e., trolox and ascorbic acid. Furthermore, mol. docking was performed to check the affinity of flavonoids with Keap1 for the activation of antioxidant defense system of body and computational study was carried out by DFT approach using B3LYP functional and 6-31G** basis set. All the compounds showed better results compared to the reference compounds and mol. docking studies supported the computational results. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary