Recommanded Product: (Bromomethyl)cyclopropaneIn 2019 ,《Introducing broadened antibacterial activity to rhodanine derivatives targeting enoyl-acyl carrier protein reductase》 appeared in Chemical & Pharmaceutical Bulletin. The author of the article were Sun, Zhi-Gang; Xu, Yun-Jie; Xu, Jian-Fei; Liu, Qi-Xing; Yang, Yu-Shun; Zhu, Hai-Liang. The article conveys some information:
Broadened antibacterial activity was introduced to rhodanine derivatives targeting Mycobacterial tuberculosis enoyl-acyl carrier protein reductase (Mtb InhA) by recruiting feature of xacins to bring DNA Gyrase B inhibitory capability. This is significant for preventing further bacterial injections in the tuberculosis treatment. The most potent compound Cy14 suggested comparable bioactivity (IC50 = 3.18 microM for Mtb InhA; IC50 = 10 nM for DNA Gyrase B) with pos. controls. Structure-activity relationship discussion and mol. docking model revealed the significance of rhodanine moiety and derived methoxyl on meta-position, pointing out orientations for future modification. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: (Bromomethyl)cyclopropane)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: (Bromomethyl)cyclopropane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary