COA of Formula: C9H9BrO2In 2021 ,《Metal-binding Q-proline macrocycles》 appeared in Journal of Organic Chemistry. The author of the article were Northrup, Justin D.; Wiener, Jesse A.; Hurley, Matthew F. D.; Hou, Chun-Feng David; Keller, Taylor M.; Baxter, Richard H. G.; Zdilla, Michael J.; Voelz, Vincent A.; Schafmeister, Christian E.. The article conveys some information:
We introduce the efficient Fmoc-SPPS and peptoid synthesis of Q-proline-based, metal-binding macrocycles (QPMs), which bind metal cations and display nine functional groups. Metal-free QPMs are disordered, evidenced by NMR and a crystal structure of QPM-3 obtained through racemic crystallization Upon addition of metal cations, QPMs adopt ordered structures. Notably, the addition of a second functional group at the hydantoin amide position (R2) converts the proline ring from Cγ-endo to Cγ-exo, due to steric interactions. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)
Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.COA of Formula: C9H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary