Formula: C11H13BrO2On May 3, 1996 ,《Synthesis and Hydrogen Bonding Capabilities of Biphenyl-Based Amino Acids Designed To Nucleate β-Sheet Structure》 appeared in Journal of Organic Chemistry. The author of the article were Nesloney, Carey L.; Kelly, Jeffery W.. The article conveys some information:
The syntheses of 3′-(aminoethyl)-2-biphenylpropionic acid (I; R = OH, R1 = H) and 2-amino-3′-biphenylcarboxylic acid (II; R = OH, R1 = H) are described. I and II were designed to nucleate β-sheet structure in aqueous solution when incorporated into small, amphiphilic peptides in place of the backbone of the i + 1 and i + 2 residues of the β-turn. Amides I and II (R = NHCH2Ph, R1 = COCH2Ph) were synthesized and studied as model compounds to investigate hydrogen-bonding capabilities. The x-ray crystal structure of I (R = NHCH2Ph, R1 = COCH2Ph) indicates that a 13-membered intramol. hydrogen-bonded ring is formed, while the remaining amide proton and carbonyl are involved in intermol. hydrogen bonding. IR and variable-temperature NMR experiments indicate that, in solution (CH2Cl2), I (R = NHCH2Ph, R1 = COCH2Ph) exists as an equilibrium mixture of the 13- and the 15-membered intramolecularly hydrogen-bonded conformers with the 15-membered ring conformer being favored. Amide II (R = NHCH2Ph, R1 = COCH2Ph) was shown to exist in solution (CH2Cl2) as an equilibrium mixture of the 11-membered intramol. hydrogen-bonded ring and a nonbonded conformation. No contribution from the 9-membered hydrogen ring conformation was observed The x-ray crystal structure of II (R = NHCH2Ph, R1 = COCH2Ph) indicated the absence of intramol. hydrogen bonding in the solid state. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1Formula: C11H13BrO2)
Ethyl 3-(2-bromophenyl)propanoate(cas: 135613-33-1) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Formula: C11H13BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary