《Synthesis of 3,4-dihydropyrimidin-2(1H)-one via retro-Biginelli reaction》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Mondal, Sudipta; Mondal, Mohabul A.. Quality Control of o-Bromobenzaldehyde The article mentions the following:
Hydrolytic behavior of 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-ones under alk. condition had been explored. Mechanistic details were established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeded through the retro-Biginelli reaction. The scope of the retro-Biginelli reaction had been explored by the synthesis of substituted DHPs I [Ar = Ph, 4-MeC6H4, 2-BrC6H4; Ar1 = Ph, 4-MeC6H4, 2-BrC6H4, 3-MeOC6H4]. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary