Kanai, Yuki; Mueller-Borges, Dorian; Plenio, Herbert published the artcile< The Regioselective Arylation of 1,3-Benzodioxoles>, Application In Synthesis of 401-78-5, the main research area is aryl benzodioxole preparation regioselective; benzodioxole aryl bromide arylation palladium catalyst.
The direct arylation of 1,3-benzodioxole and 2,2-difluorobenzo[1,3]dioxole with different aryl bromides RBr (R = 4-methylphenyl, naphthalen-1-yl, 9,9-diethyl-9H-fluoren-2-yl, etc.) yields the resp. 4-substitued products I (R1 = H, F) in yields of >80% requiring between 0.05-1 mol% Na2PdCl4, 30 mol% pivalic acid, 1.3 equivalents K2CO3 and ca. 250 equivalents of diethylacetamide per Pd at T = 120°C. The nature of the amide and the concentration of the reactants are crucial for the optimization of the reaction conditions. The primary role of the acetamide is that of a ligand to Pd, it is not needed as a solvent.
Advanced Synthesis & Catalysis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary