《Reaction of Vinyl Aziridines with Arynes: Synthesis of Benzazepines and Branched Allyl Fluorides》 was published in Chemistry – A European Journal in 2020. These research results belong to Kaldas, Sherif J.; Kran, Eva; Mueck-Lichtenfeld, Christian; Yudin, Andrei K.; Studer, Armido. Recommanded Product: 1779-49-3 The article mentions the following:
The cycloaddition between vinyl aziridines I [R1 = benzyl, cyclohexyl, (4-methoxyphenyl)methyl; R2 = H, Me; R3 = H, Me; R4 = H, Ph] and arynes R5OS(O)2Ar (R5 = 2-iodophenyl, 4-fluoro-3-iodophenyl, 2-iodo-6-methoxyphenyl, etc.; Ar = trifluoromethyl, 4-chlorophenyl, 4-fluorophenyl, 4-iodophenyl) was reported. Depending on the reaction conditions and the choice of the aryne precursor, the aziridinium intermediate can be trapped through two distinct mechanistic pathways. The first one proceeds through a formal [5+2] cycloaddition to furnish valuable multi-substituted benzazepines II (R6 = H, 6-OMe, 6,8-(CH3)2, 6-F, etc.). In the second pathway, the aziridinium is intercepted by a fluoride ion to afford allylic fluorides R7N(R8)CH(R9)CH(F)C(=CH2)R10 (R7 = Ph, 3-methoxyphenyl, 3,4-difluorophenyl, etc.; R8 = benzyl, cyclohexyl, (4-methoxyphenyl)methyl; R9 = H, Me; R10 = H, Me) in good yields. Both reactions proceed stereospecifically and furnish enantiopure benzazepines II and allylic fluorides. After reading the article, we found that the author used Methyltriphenylphosphonium bromide(cas: 1779-49-3Recommanded Product: 1779-49-3)
Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Recommanded Product: 1779-49-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary