《Total Synthesis of Viridin and Viridiol》 was written by Ji, Yang; Xin, Zhengyuan; He, Haibing; Gao, Shuanhu. Electric Literature of C19H18BrPThis research focused onviridin viridiol total asym synthesis cycloaddition radical cyclization. The article conveys some information:
The asym. total syntheses of (-)-viridin (I) and (-)-viridiol (II), antifungal metabolites, were achieved in 17 and 18 steps, resp., from a com. available starting material. An intramol. [3+2]-cycloaddition was applied to an easily available L-ribose derivative in order to construct the highly substituted D ring containing the key chiral cis-triol fragment. Co-catalyzed metal-hydride H atom transfer (MHAT) radical cyclization was utilized to form the C-ring and the all-carbon quaternary center at C-10. This convergent strategy provides a scalable approach to prepare viridin and viridiol for biol. studies. In the experiment, the researchers used Methyltriphenylphosphonium bromide(cas: 1779-49-3Electric Literature of C19H18BrP)
Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Electric Literature of C19H18BrP
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary