《Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Fotsing, Joseph R.; Darmohusodo, Vincent; Patron, Andrew P.; Ching, Brett W.; Brady, Thomas; Arellano, Melissa; Chen, Qing; Davis, Timothy J.; Liu, Hanghui; Servant, Guy; Zhang, Lan; Williams, Mark; Saganich, Michael; Ditschun, Tanya; Tachdjian, Catherine; Karanewsky, Donald S.. Name: Methyl 3-(bromomethyl)benzoate The article mentions the following:
In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blockers that can either suppress or reduce the bitterness of these compounds have not been described. We are hereby reporting a series of novel 3-(pyrazol-4-yl) imidazolidine-2,4-diones as potent and selective TAS2R8 antagonists. In human sensory tests, S6821(I) and S7958(II), two of the most potent analogs from the series, demonstrated efficacy in blocking TAS2R8-mediated bitterness and were selected for development. Following data evaluation by expert panels of a number of national and multinational regulatory bodies, including the US, the EU, and Japan, S6821 and S7958 were approved as safe under conditions of intended use as bitter taste blockers. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Name: Methyl 3-(bromomethyl)benzoate The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary