Djukanovic, Dimitrije; Heinz, Benjamin; Mandrelli, Francesca; Mostarda, Serena; Filipponi, Paolo; Martin, Benjamin; Knochel, Paul published the artcile< Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene>, Reference of 401-78-5, the main research area is acylation aromatic amide urea aryllithium preparation aryl diaryl ketone; aryl ketone functionalized unsym preparation acylation aryllithium amide urea; flow reaction acylation aryllithium amide urea preparation ketone; acylation; amide; continuous flow; lithium; toluene.
The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25° within 40 s the corresponding aryllithiums which were acylated with various functionalized N,N-dimethylamides including easily enolizable amides at -20° within 27 s, producing highly functionalized ketones in 48-90% yield (36 examples). This method was well suited for the preparation of α-chiral ketones such as naproxen and ibuprofen derived ketones with 99% ee. A one-pot stepwise bis-addition of two different lithium organometallics to 1,1,3,3-tetramethylurea (TMU) provided unsym. ketones in 69-79% yield (9 examples).
Chemistry – A European Journal published new progress about Acylation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Reference of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary