Electric Literature of C9H9BrO2In 2016 ,《Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors》 appeared in Organic & Biomolecular Chemistry. The author of the article were De Vreese, Rob; Depetter, Yves; Verhaeghe, Tom; Desmet, Tom; Benoy, Veronick; Haeck, Wanda; Van Den Bosch, Ludo; D’hooghe, Matthias. The article conveys some information:
The synthesis of novel isoform-selective HDAC inhibitors is considered to be an important, emerging field in medicinal chem. In this paper, the preparation and assessment of thirteen selective HDAC6 inhibitors is disclosed, elaborating on a previously developed thiaheterocyclic Tubathian series. All compounds were evaluated in vitro for their ability to inhibit HDAC6, and a selection of five potent compounds was further screened toward all HDAC isoforms (HDAC1-11). The capability of these Tubathian analogs to inhibit α-tubulin deacetylation was assessed as well, and ADME/Tox data were collected. This thorough SAR evaluation revealed that the oxidized, para-substituted hydroxamic acids can be recognized as valuable lead structures in the pursuit of novel potent and selective HDAC6 inhibitors. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Electric Literature of C9H9BrO2)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Electric Literature of C9H9BrO2Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary