In 2019,ACS Combinatorial Science included an article by de Pedro Beato, Eduardo; Priego, Julian; Gironda-Martinez, Adrian; Gonzalez, Fernando; Benavides, Jesus; Blas, Jesus; Martin-Ortega, Maria Dolores; Toledo, Miguel Angel; Ezquerra, Jesus; Torrado, Alicia. Formula: C7H5BrO2. The article was titled 《Mild and Efficient Palladium-Mediated C-N Cross-Coupling Reaction between DNA-Conjugated Aryl Bromides and Aromatic Amines》. The information in the text is summarized as follows:
DNA-encoded library technol. (ELT) has emerged in the pharmaceutical industry as a powerful tool for hit and lead generation. Over the last 10 years, a number of DNA-compatible chem. reactions have been published and used to synthesize libraries. Among the most commonly used reactions in medicinal chem. is the C-N bond formation, and its application to DNA-encoded library technol. affords an alternative approach to identify high-affinity binders for biol. relevant protein targets. Herein we report a newly developed Pd-promoted C-N cross coupling reaction between DNA-conjugated aryl bromides and a wide scope of arylamines in good to excellent yields. The mild reaction conditions should facilitate the synthesis of novel DNA-encoded combinatorial libraries. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary