Chen, Dake; Berhane, Ilyas A.; Chemler, Sherry R. published the artcile< Copper-Catalyzed Enantioselective Hydroalkoxylation of Alkenols for the Synthesis of Cyclic Ethers>, Name: Methyl 3-bromo-2-(bromomethyl)benzoate, the main research area is THF phthalan isochroman morpholine enantioselective preparation; copper catalyst enantioselective intramol hydroalkoxylation alkenol.
In the presence of Cu(OTf)2 and a nonracemic bis(oxazoline), terminal and 1,1-disubstituted and 1,2-disubstituted alkenols such as I underwent enantioselective intramol. hydroalkoxylation with 1,4-cyclohexadiene as a reducing agent and either MnO2 or Ag2CO3 as oxidant in PhCF3 to yield nonracemic cyclic ethers such as II. Tetrahydrofurans, phthalans, isochromans, and morpholines were prepared from 4- and 5-alkenols using this method; the substrate scope is complementary to existing enantioselective alkene hydroalkoxylations and is broad with respect to substrate backbone and alkene substitution. The method was used for an enantioselective preparation of the antifungal insecticide furametpyr. A polar/radical mechanism involving enantioselective oxycupration followed by homolysis of the copper-carbon bond and hydrogen atom transfer is proposed.
Organic Letters published new progress about Alkenyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, Name: Methyl 3-bromo-2-(bromomethyl)benzoate.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary