The author of 《Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors》 were Chen, Chen; Yang, Xinying; Fang, Hao; Hou, Xuben. And the article was published in European Journal of Medicinal Chemistry in 2019. Synthetic Route of C4H7BrO2 The author mentioned the following in the article:
8-Hydroxyquinoline-substituted amides such as I were prepared as matrix metalloproteinase-2 and -9 (MMP-2/MMP-9) inhibitors for potential use in treating cancer. I and a related indolylethylamide inhibited MMP-2 and MMP-9 with IC50 values of 0.66-1.3 μM, inhibited the proliferation of human cancer cells with IC50 values of 0.69-22 μM, and inhibited angiogenesis while inhibiting human non-tumor cell growth with IC50 values > 50 μM. I and a related indolylethylamide down-regulated the expression of MMP-2 and MMP-9 in A549 cells; I promoted the apoptosis of A549 cells in vitro. Mol. docking calculations of I in the active sites of MMP-2 and MMP-9 were performed. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary