Recommanded Product: 586-76-5In 2021 ,《Synthesis and Acidity of 5-(m-Terphenyl-2′-yl)-1H-tetrazoles: Evidence for an Enhanced Polar-π Effect Compared to Carboxylic Acids》 was published in Journal of Medicinal Chemistry. The article was written by Bookser, Brett C.; Do, Quyen-Quyen; Sritana-Anant, Yongsak; Baldridge, Kim K.; Siegel, Jay S.. The article contains the following contents:
The polar-π effect on tetrazoles, medicinal chem. isosteres of carboxylate, is tested by a Hammett pKa (microtitration) anal. over a series of 5-(m-terphenyl-2′-yl)-1H-tetrazoles. A comparison with m-terphenyl-2′-yl-carboxylic acids supports the isostere analogy also in response to environmental changes. Computational (B97D/def2TZVPPD) extension of the series plus a scan of solvents (vacuum to water) demonstrates the trend with the dielec. constant The effect is energetically small but may make statistically significant contributions to the tetrazole pharmacol. profile. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 586-76-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary