In 2017,Zhu, Ru-Yi; Saint-Denis, Tyler G.; Shao, Ying; He, Jian; Sieber, Joshua D.; Senanayake, Chris H.; Yu, Jin-Quan published 《Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds》.Journal of the American Chemical Society published the findings.Application In Synthesis of Methyl 3-bromopropanoate The information in the text is summarized as follows:
We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp3)-H bromination, enabled by quinoline ligands. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Application In Synthesis of Methyl 3-bromopropanoate)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application In Synthesis of Methyl 3-bromopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary