Zhang, Zeyuan; Dai, Zhen; Ma, Xinkun; Liu, Yihan; Ma, Xiaojun; Li, Wanli; Ma, Chen published the artcile< Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp2 C-H and O-H cross-dehydrogenative coupling>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is oxazepinone preparation; benzamide quinolinyl phenol halo cross dehydrogenative coupling copper catalyst.
An efficient Cu-catalyzed cascade reaction protocol was developed for the synthesis of fused oxazepinone derivatives I (R1 = H, 7-Cl, 8-Me, 9-CF3, etc.; R2 = H, 3-Br, 4-Cl, 3-MeO, etc.; Q = quinolin-8-yl, 5-methoxyquinolin-8-yl; A = N, C) via sp2 C-H and O-H cross-dehydrogenative coupling. A readily available catalyst, Cu2O, was used in this modular and convergent approach. An unusual Smiles rearrangement reaction was involved in this synthesis. Various reaction parameters were evaluated and optimized and the target compounds were obtained in good-to-excellent yields.
Organic Chemistry Frontiers published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary