Zaja, Mirko; Connon, Stephen J.; Dunne, Aideen M.; Rivard, Michael; Buschmann, Nicole; Jiricek, Jan; Blechert, Siegfried published the artcile< Ruthenium olefin metathesis catalysts with modified styrene ethers: influence of steric and electronic effects>, Name: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is ruthenium isopropoxybenzylidene complex preparation ring closing metathesis catalyst; functionalized styrene ether preparation reaction ruthenium complex; diene ruthenium complex catalyzed metathesis steric hindrance electronic effect; heterocyclic compound nitrogen dihydropyrrole hexahydroazocine preparation.
A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesized, and the effects of ligands on the rate of metathesis was investigated. Increased steric hindrance ortho to the isopropoxy group enhanced reaction rates. In the case of N-heterocyclic carbene complexes, decreasing electron d. at both the chelating oxygen atom and the Ru:C bond accelerated reaction rates appreciably. In an example reaction, CH2:CHCH2N(Ts)CH2CH:CH2 underwent ring-closing metathesis in the presence of (4,5-dihydroIMes)Cl2Ru:CH(2-OiPr)(4-CN)C6H3 giving N-tosyl-2,5-dihydropyrrole in 96% yield. Catalysts containing a tricyclohexylphosphine ligand, such as (PCy3)Cl2Ru:CH(2-OiPr)(5-CF3)C3H6, followed the same trend with regard to benzylidene electrophilicity, while higher electron d. at oxygen enhanced reaction rates.
Tetrahedron published new progress about Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Name: 2-Bromo-4-(trifluoromethyl)phenol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary