Related Products of 14660-52-7In 2020 ,《Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yao, Dahong; Li, Chenyang; Jiang, Jin; Huang, Jian; Wang, Jinhui; He, Zhendan; Zhang, Jin. The article conveys some information:
The dysfunction of histone deacetylase (HDACs) is closely related to tumorigenesis and development, which has been emerged as an attractive drug design target for cancer therapy. In the present study, a series of novel HDAC inhibitors using a substituted quinazoline as the capping group and attaching 3,5-dimethylbenyl as a potential metabolic site protector have been designed and synthesized. Compounds I and II demonstrated potent HDAC inhibitory activities and anti-proliferative effects against MDA-MB-231 cells. In addition, I and II both could significantly increase the acetylation level of intracellular proteins, especially in α-Tubulin and HSP90. Compounds I and II displayed a slight different anti-tumor mechanism, I mainly induced apoptosis while II induced obviously ER-Stress. Furthermore, I and II both induced autophagy and migration inhibition. In pharmacokinetics assay, I showed a significant improvement of pharmacokinetic profile for oral administration. Addnl., I presented more potent anti-proliferation and anti-migration activity than SAHA in zebrafish MDA-MB-231 cell line-derived xenograft model. Together, these results demonstrate that I is a novel oral HDAC inhibitor with a potential capacity of treating breast cancer. The results came from multiple reactions, including the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary