《Tumor-Triggered Disassembly of a Multiple-Agent-Therapy Probe for Efficient Cellular Internalization》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Yang, Juliang; Dai, Jun; Wang, Quan; Cheng, Yong; Guo, Jingjing; Zhao, Zujin; Hong, Yuning; Lou, Xiaoding; Xia, Fan. COA of Formula: C6H12Br2 The article mentions the following:
Integration of multiple agent therapy (MAT) into one probe is promising for improving therapeutic efficiency for cancer treatment. However, MAT probe, if entering the cell as a whole, may not be optimal for each therapeutic agent (with different physicochem. properties), to achieve their best performance, hindering strategy optimization. A peptide-conjugated-AIEgen (FC-PyTPA) is presented: upon loading with siRNA, it self-assembles into FCsiRNA-PyTPA. When approaching the region near tumor cells, FCsiRNA-PyTPA responds to extracellular MMP-2 and is cleaved into FCsiRNA and PyTPA. The former enters cells mainly by macropinocytosis and the latter is internalized into cells mainly through caveolae-mediated endocytosis. This two-part strategy greatly improves the internalization efficiency of each individual therapeutic agent. Inside the cell, self-assembly of nanofiber precursor F, gene interference of CsiRNA, and ROS production of PyTPA are activated to inhibit tumor growth. After reading the article, we found that the author used 1,6-Dibromohexane(cas: 629-03-8COA of Formula: C6H12Br2)
1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.COA of Formula: C6H12Br2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary