Takeda, Mitsumi; Maejima, Saki; Yamaguchi, Eiji; Itoh, Akichika published the artcile< Iodine-mediated direct α-amination of dimethyl methylmalonate using non-protected amines>, SDS of cas: 3959-07-7, the main research area is dimethyl methylmalonate amine iodine regioselective amination; alkylamino dimethyl methylmalonate preparation.
In this study, direct C-N bond formation was achieved via the reaction of a di-Me methylmalonate with various amines in the presence of mol. iodine to produce α-aminocarbonyl compounds This versatile methodol. of the α-amination of a carbonyl-containing compound involves the in situ iodination of the di-Me methylmalonate, thus promoting the formation of its enolate isomer, which then facilitates its nucleophilic substitution reaction with an amine. This strategy is highly practical and can be used in industry due to its requirement of only readily available reagents without any pre-preparation of the amines and other substrates.
Tetrahedron Letters published new progress about Amination, regioselective. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary