Sun, Yumeng; Li, Yueshan; Miao, Zhuang; Yang, Ruicheng; Zhang, Yun; Wu, Ming; Lin, Guifeng; Li, Linli published an article in 2021. The article was titled 《Discovery of 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives as a new class of ROCK inhibitors for the treatment of glaucoma》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Product Details of 1129-28-8 The information in the text is summarized as follows:
The Rho-associated protein kinases (ROCKs) are associated with the pathol. of glaucoma and discovery of ROCK inhibitors has attracted much attention in recent years. Herein, we report a series of 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives as a new class of ROCK inhibitors. Structure-activity relationship studies led to the discovery of compound 12b, which showed potent activities against ROCK I and ROCK II with IC50 values of 93 nM and 3 nM, resp. 12b also displayed considerable selectivity for ROCKs. The mean IOP-lowering effect of 12b in an ocular normotensive model was 34.3%, and no obvious hyperemia was observed Overall, this study provides a good starting point for ROCK-targeting drug discovery against glaucoma. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Product Details of 1129-28-8)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Product Details of 1129-28-8Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary